Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males.

As shown in Table 2 , although in our GWAS none of the two SOX6 gene SNPs achieved nominally significant p values ( p <0.05) for univariate association with BMI, FM or hip BMD, both SNPs achieved p values of 10 −6 to 10 −7 for bivariate association with BMI-hip BMD or FM-hip BMD.

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However, at the bivariate level, the SNPs achieved highly significant p values for bivariate association with FM-hip BMD ( Table 2 ).

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