One single VPA dose further reduced brain-specific RNA 13 C labeling to 1.15% (SD = 0.26), which closely approached significance by a “ P ” value of 0.072 using the more severe two-tailed “ t ” test.
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Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-C(6)]-d-glucose tracer in mice.
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