Barely Significant
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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.

Diabetes Care · 2009 · PMC2732153 · PMID 19564453

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a clear trendno p-value reported
Although none of the risks for low, medium, and high doses stratified by length of follow-up were significantly different from each other (as indicated by overlapping CIs), there was a clear trend for metformin users to have a higher risk of cancer in the first 2 years of follow-up.

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