Gene copy number variation throughout the Plasmodium falciparum genome.

Overall, there was a highly significant skew toward sub-telomeric location for CNV genes compared with non-CNV genes ( p < 0.0001, Kolmogorov-Smirnov test; Figure 1B , Table 1 ).

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falciparum genome are exported to the infected erythrocyte cell surface and possess transmembrane domains, though we found no excess of CNV among genes containing the major signal peptide associated with export to the cell surface (the PEXEL motif), and only a weakly significant excess of genes containing transmembrane domains (Table 1 ).

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