Preserving cognitive function for patients with overactive bladder: evidence for a differential effect with darifenacin.

Tolterodine had no effect at lower doses (0.3 or 0.1 mg/kg), but showed a trend for impaired learning at the highest dose (1 mg/kg; p = 0.054 for the reduction in latency), although this represents 100× the doses of tolterodine required to affect bladder contractions (assessed as inhibition of carbachol-induced increase in intravesical pressure).

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