International guidelines for management of metastatic breast cancer: combination vs sequential single-agent chemotherapy.

J Natl Cancer Inst · 2009 · PMC2736293 · PMID 19657108

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did not reach statistical significanceno p-value reported

In a study in Australia, 3-weekly paclitaxel monotherapy was associated with a similar RR, TTF, and QoL when compared with cyclophosphamide-methotrexate-5-FU-prednisone, with a trend toward an improved OS that did not reach statistical significance ( 41 ).

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