These peptides failed to elicit significant protection in the urine, bladder, or kidneys of mice, however, there was nearly a 2-log reduction in CFU/g in the kidneys for both IroN ( P = 0.053) and IutA ( P = 0.078) peptides, demonstrating a strong trend towards protection ( Fig. 1F ).
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Mucosal immunization with iron receptor antigens protects against urinary tract infection.
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