Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping.

Furthermore, statistical analyses showed a slight trend for the presence of AI at 5q21 correlating with the poor response to chemotherapy, in agreement with a trend towards a worse prognosis in case of AI at 5q21.

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In one study, the site of the primary tumour had no correlation with survival ( Nagler et al , 2000 ), whereas others have reported a significant trend towards survival in the axial or appendicular flat bone high-grade osteosarcomas ( Duffaud et al , 2000 ; Gadwal et al , 2001 ).

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