Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.

The analysis of Belgian CD trios revealed only nominally significant associations with the major alleles (i.e. allele frequency in controls >50%) of four SNPs, three of which are located in the haplotype block encompassing the region covering the MEFV promoter to intron 2 and its 5′ flanking region (rs182674( A ): p = 0.029; rs224217( G ): p = 0.052; rs224231( G ); p = 0.039; rs6501170( T ): p = 0.016; the risk nucleotides are indicated in brackets) ( Figure 2A , Table S1 ).

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