BRCA1 and BRCA2 mutations in Scotland and Northern Ireland.

An international collaborative study ( Neuhausen et al , 1998 ) provided some supporting evidence which, however, failed to reach statistical significance.

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Taking the 3′ end of exon 11 as the potential ‘change point’, we found a highly significant difference in the relative proportions of breast and ovarian cancers ‘upstream’ and ‘downstream’ of this position.

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