A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.

The relative level of STAT5 tyrosine phosphorylation was slightly reduced in the triple mutant as compared to wild type, but did not reach statistical significance ( Figure 5A ; p = 0.061), consistent with findings described above ( Figure 4E ).

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