Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons.

J Neurodev Disord · 2009 · PMC2758250 · PMID 19816534

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Compared to their wild-type littermates, Dlx1 −/− mice showed a trend towards decreased prepulse inhibition at all prepulse intensities that were tested (8 dB, 12 dB, and 16 dB above the background of 60 dB white noise) (mean±SEM: at 8 dB Dlx1 +/+ 45.8 ± 5.4%, Dlx1 −/− 30.9 ± 3.2%; at 12 dB Dlx1 +/+ 47.4 ± 4.9%, Dlx1 −/− 38.1 ± 8.7%; at 16 dB Dlx1 +/+ 51.2 ± 3.6%, Dlx1 −/− 43.1 ± 7.5%; overall ANOVA p < 0.05).

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