The effect of offspring gender in the FX premutation mice is not related to skewed transmission of the mutant Atm allele since the difference in expansion frequency did not reach statistical significance in Atm +/+ and Atm +/− progeny irrespective of whether the premutation allele was maternally or paternally transmitted (data not shown).
← all excerpts
ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.
1
—
—