Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatum.

Fra1 expression showed significant METH challenge-induced increases in the absence of METH preconditioning whereas the increases in the MM group did not reach statistical significance ( Fig. 5B ) There were significant increases in Fra2 expression in the SM group in comparison to both the SS and the MS group whereas the increased observed in the MM group were significantly different from the MS group ( Fig. 5C ).

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