Examination of islets smaller or larger than 1,000 beta-cells revealed that the percentage of TUNEL positive beta-cells was modestly higher in WT-βTag mice compared to PKO-βTag mice for both islet size classes ( Figure 4A–C ) but did not reach statistical significance.
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PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.
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