Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.

There was predominantly a candidate gene approach using common alleles, which despite small sample sizes (median 93 [IQR 40–222]) with no trend to an increase over time, generated a high proportion (74.5%) of nominally significant (p<0.05) reported associations suggesting the possibility of significance-chasing bias.

also in 7,732 other papers