Barely Significant
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High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model.

PLoS One · 2009 · PMC2780715 · PMID 19997632

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Although the mean IFA titer of AMA+ISA FCH/4 group (22,528) was 4 times higher than that of the AMA+AS02 A-FCH/4 group (5,291) this difference also did not reach statistical significance as was observed with ELISA titers.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.