Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4.

Although serum IL-17 levels were fairly uniform among arthritic and non-arthritic mice, the collagen-specific Th17 responses in the lymphoid organs were much more variable and there was a trend towards increased IL-17 in arthritic mice (although it did not reach statistical significance).

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