Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro.

Arthritis Res Ther · 2009 · PMC2787293 · PMID 19778432

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showed a trendno p-value reported

However, the TNFα-induced GAG release was significantly reduced by TIMP-3 by approximately 52% (Figure 1c ), whereas TIMP-1 and TIMP-2 showed a trend to increase the TNFα-induced GAG release, although this effect was not significant.

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