As slower islets showed a trend, albeit non-significant, to have slower single cells than faster islets, it is possible that the oscillation periods of single cells do reflect imprinting, but that this is obscured by the vastly increased heterogeneity of the single cells apparent in Fig. 4 and anticipated from theoretical modeling [53] .
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Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.
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