On average, responders did not reach the minimum clinically important difference in health status (0.29 points/year, P = 0.05), although a borderline significant effect of inhaled fluticasone was noted.
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Predictive value and utility of oral steroid testing for treatment of COPD in primary care: the COOPT study.
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The sentences
Possible clinically relevant reductions in exacerbation rate (rate ratio 0.67) and FEV 1 decline (39 mL/year) occurred in responders, but did not reach statistical significance.