highly significantP<0.0001
In the entire PRDM9 protein of 894 amino acids, only 96 amino acids are in a DNA-binding turn-helix region (8 in each of 12 ZF domains), indicating a highly significant enrichment of nonsynonymous SNPs in turn-helix residues (24/31 vs. 96/894, P<0.0001 by Fisher's exact test).