Do BIG1-98 and ZOFAST demand a change in guidelines for endocrine therapy?

Breast Cancer Res · 2009 · PMC2797698 · PMID 20030869

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did not quite reach statistical significanceno p-value reported

In the intent-to treat overall survival analysis there was a very strong trend in favour of letrozole over tamoxifen that did not quite reach statistical significance, with a hazard ratio of 0.7 (95% confidence interval, 0.75 to 1.02).

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a strong trendno p-value reported

Upfront letrozole treatment for 5 years, however, showed a strong trend towards superiority over starting with tamoxifen for 2 years and then switching to 3 years of letrozole treatment.

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