A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.

Environ Health Perspect · 2009 · PMC2801168 · PMID 20049115

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a significant trendno p-value reported

(2007a) found that DEHP (100 or 500 ppm) induces liver tumors in PPAR-α–null mice and they also reported a significant trend for the observed increase in total liver tumors with DEHP in PPAR-α–null male mice with Sv129 genetic background generated as described in Lee et al.

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