Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells.

Mol Cancer · 2009 · PMC2804606 · PMID 20030852

Europe PMC DOI

hedged sentences

0.0237

closest p · 0.5× alpha

0.0237

boldest claim

The sentences

a significant trendp = 0.0237actually significant

During the progression from normal human melanocytes (n = 1) over melanoma in situ (n = 2) and primary melanoma (n = 14) to metastatic melanoma (n = 41) there is a significant trend of increase of CXCL1 gene expression (p = 0.0237).

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highly significantno p-value reported

Only the combination of knocking down ABCA1 together with simultaneous application of Curcumin results in a statistically highly significant response in terms of apoptosis.

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