The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice.

Although there is functional receptor-mediated cholesterol uptake in livers of CETP Tg mice, the moderate decrease of plasma [ 3 H]-cholesterol by T-0681 in the RCT study did not reach statistical significance, and fecal output of [ 3 H]-sterols was found unaffected upon treatment.

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