Genome wide association for addiction: replicated results and comparisons of two analytic approaches.

These analyses have focused on identification of nominally significant case vs control allele frequency differences at several nearby SNP markers in multiple independent samples.

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We would anticipate the observed, highly significant clustering of SNPs that display nominally positive results if many of these reproducibly positive SNPs lay near and were in linkage disequilibrium with functional allelic variants that distinguished substance dependent subjects from control subjects, but not if they represented chance observations.

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