Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons.

(Fasted levels were also lower in Pomc-KI versus wild-type mice, but the difference failed to reach statistical significance.) To further demonstrate that the observed reduction in Abcc8 expression was linked to InsR signaling in POMC neurons, we measured hypothalamic Abcc8 mRNA in mice lacking the insulin-regulated transcription factor forkhead box class O (FoxO1) in POMC neurons ( Foxo1 ΔPOMC ).

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