Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

Recipients of Treg-conditioned DC that were incubated with anti–PD-L1 prior to adoptive transfer had lower numbers of PD-L1–expressing DC in vivo, although cohort comparisons did not reach statistical significance ( Figure 3C (i) ); a repeat experiment yielded similar findings (unpublished data).

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