Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers.

Toxicol Sci · 2010 · PMC2819973 · PMID 20026473

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an important trendno p-value reported

An important trend in current toxicology is the replacement, reduction, and refinement of the use of experimental animals (the 3R principle).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.