Thiazolidinediones and cardiovascular risk - a question of balance.

Curr Cardiol Rev · 2009 · PMC2822138 · PMID 20676274

Europe PMC DOI

hedged sentences

0.0950

closest p · 1.9× alpha

0.0950

boldest claim

The sentences

a statistical trendp=0.095so close (0.05 < p ≤ 0.1)

This prospective, randomized, placebo-controlled study showed that, over approximately 3 years, pioglitazone therapy was associated with a statistical trend towards benefit (hazard ratio [HR]=0.90, 95% confidence interval [CI] [0.80, 1.02], p=0.095) for the primary composite macrovascular end point (a complex composite of cerebral, cardiac and peripheral events and both disease-related and procedural end points).

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failed to reach significanceno p-value reported

A subsequent analysis of MI alone from this dataset, however, showed an increased risk that failed to reach significance (OR=1.59, 95% CI [0.93, 2.71]) [73].

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showed a trendno p-value reported

[ 72 ]), they all showed a trend towards increased risk.

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