Highly expressed and slowly evolving proteins share compositional properties with thermophilic proteins.

If the analysis is restricted to ortholog pairs with estimated d S < 1, a strong trend toward agreement is observed ( table 2 ), comparable to that found in other organisms and statistically significant ( P = 0.031 for d N/ d S and P = 0.0078 for the other measures of protein evolutionary rate).

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In figure 1 B , an increasing trend is obvious for three of the amino acids that are less frequent in thermophilic proteins: C, T, and W.

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It may be significant that D. melanogaster and S. cerevisiae are also the only organisms that required correction for GC content in order to show the observed effect.

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