When sex, smoking, hypertension and hypercholesterolaemia were adjusted for, the haplotype effect remained nominally significant ( P = 0.05) in young onset CAD cases, more so ( P = 0.002) when hypercholesterolaemia was excluded.
Considered individually, each of the traditional risk factors of CAD [male gender, diabetes, hypertension, hypercholesterolaemia, cigarette smoking and body mass index (BMI)] has a highly significant effect on disease risk.
Other SNPs or haplotype associations marginally significant in this study were found in IL9, C5, IL4R and SCYA11 (Tables 3 and 4 ).