Not only are the correlations highly significant for infected implants in statistical terms (e.g., P <0.0001 for CCR5 + ITTP versus both Gag-p24 + ITTP and thymocyte viability), but the proportion of CCR5 + ITTP corresponds closely to that of infected ITTP ( Figure 4A ).
Although the decreases in implant cellularity, thymocyte viability, and percentage of DP thymocyte were often not statistically significant when individual experiments were compared (likely the result of the small number of mock-infected mice), animals in the R5 HIV-infected cohorts showed a trend towards decreases in each of these parameters.