Pretreatment CD4 cell slope and progression to AIDS or death in HIV-infected patients initiating antiretroviral therapy--the CASCADE collaboration: a collaboration of 23 cohort studies.

By contrast, CD4 cell count and age remained highly significant predictors in this subgroup.

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We confirm the existence of such a small effect in our supplementary analysis of 3,078 patients from the pre-cART era but note that the effect did not reach statistical significance in patients with a CD4 cell count >350 cells/μl, the patient subgroup for whom a rapid CD4 decline is considered relevant under current guidelines.

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