Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.

Control subjects also showed an increased ERRα gene expression (2.2-fold increase), although this did not reach statistical significance and no changes in the gene expression of PGC-1β, porin, Mfn2, or the mitochondrial gene COXIII ( Fig. 1 C ).

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