Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.

Although the lack of highly significant association in the retinopathy group is likely attributable to power, it is possible that other influences play a greater role in determining serum ADMA levels once microvascular damage has occurred.

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In the blinding diabetic retinopathy cases, rs669173 (p = 0.017 in the additive model), and rs7521189 (p = 0.023 in the additive model) were nominally significant, however did not survive correction for multiple testing ( Table 2 ).

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