highly significantP < 0.0001
Quantitation of binding by qPCR confirms that it is highly significant ( P < 0.0001; Supplementary Figure S8 ).
Quantitation of binding by qPCR confirms that it is highly significant ( P < 0.0001; Supplementary Figure S8 ).
Three different siRNAs targeting three different exons of DRAP1 were analysed, but although DRAP1 protein levels were reduced by about 75%, only marginal changes in pre-tRNA and other pol III transcript levels were obtained, that were not consistent and did not reach statistical significance ( Figure 5 and Supplementary Figures S6 and S7 ).