M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment.

1b ), a defect that was partially restored in the complemented mutant ( P < 0.005), and a 28% reduction in adherence to HEp-2 human pharyngeal epithelial cells ( P < 0.05); although the observed partial complementation (~12%) of the latter defect did not reach statistical significance.

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