Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.

33.76 ± 2.79 μmol · l −1 · min; P < 0.001), marginally significant in IFG/IGT versus NGT (49.69 ± 4.59 vs. 39.50 ± 2.59; P = 0.059), and similar in metabolic syndrome versus non–metabolic syndrome (47.74 ± 3.66 vs. 40.12 ± 2.78).

also in 26,082 other papers

We observed a reduction in SIRT6 and SIRT7 expression in metabolic syndrome, which did not reach statistical significance but deserves further investigation because SIRT6 has been recently described as a critical factor in mammalian aging, as its absence creates a remarkable phenotype in rodents that includes metabolic alterations, loss of subcutaneous fat, and premature death ( 43 ).

also in 111,027 other papers