Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.

PLoS One · 2010 · PMC2848851 · PMID 20368992

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantp = 0.05actually significant

We had 80% power to detect nominally significant associations (p = 0.05) with SNPs that account for at least 0.8% of a trait's variance (full sample) or at least 1.0% of variance (individuals with MRIs).

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a weak trendno p-value reported

When CD40 (rs6074022) results were stratified by sex, there was a weak trend towards a stronger effect in males than females (coefficients −3.1247 and −1.1795 respectively), and a weak trend towards a stronger effect in HLA-DR15 negative individuals than HLA-DR15 positive individuals (coefficients −1.8818, and −0.9834 respectively), but these trends were not significant (interaction p-values 0.475 and 0.224, respectively) ( Table 4 ).

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