Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease.

When allele frequencies were compared between cases and controls (Table 3 ), haplogroup X showed a trend toward greater disease risk (p = 0.01); however, this association was not significant after controlling for multiple testing (even when only considering testing each of the ten haplogroups separately (rather than in combinations), which requires a Bonferroni correction of alpha = 0.005).

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