Over-expression of SOCS3 led to a significant reduction in IFN-α-induced signal transduction in the 1259 MEL cell line (p = 0.0052), but this did not reach statistical significance in the HT144 cell line (Figure 3a-b ; p = 0.087).
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Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells.
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0.0870