DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.

The findings for GSTP1 and ABCB1 might indicate a treatment specific effect on survival Survival analysis in the doxorubicin treated cohort based on the logrank test indicated that TP53 mutation status (p = 0.001), grade (p = 0.001) and the estrogen receptor status (p = 0.002) could slightly better differentiate two survival groups in the analyzed sample collection when compared to the methylation status of the single genes ( ABCB1 (p = 0.004), GSTP1 (p = 0.004) and FOXC1 (p = 0.021)), while separation based on the progesterone receptor status and amplification of ERBB2 or TOP2A did not reach statistical significance.

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