Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice.

Statistically significant differences, however, were consistently found only when comparing B10 and B10/ScN mice, while results with B6 and Tlr4 − /− were more variable and did not reach statistical significance ( Figure 4G and H ).

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