DISCUSSION The results from our epidemiologic analysis suggest that the rare allele of XRCC1 R194W increases breast cancer risk, while the rare alleles of XRCC1 R280H and XRCC1 R399Q decrease risk among women from high-risk families, though these findings were only marginally significant with XRCC1 399Q.
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XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study.
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