Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans.

For the combined data from both cohorts, the correlation ( r = 0.27) was highly significant ( p < 0.001).

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CH223191 inhibited serum AhR agonist activity in samples from cohort 2, cohort 3, and the four commercial samples, although inhibition of activity in the Dynal serum failed to reach statistical significance ( Figure 5B ).

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