Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.

The level of IR-induced breaks appeared to be higher in Rnf8 −/− cells than WT controls, although this difference did not reach statistical significance (P = 0.22).

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Remarkably, the fold differences between WT and Rnf8 −/− colony numbers displayed an increasing trend with increased IR dosages (2 Gy, 3.3-fold difference; 4 Gy, 4.3-fold difference; 6 Gy, 13.2-fold difference).

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