Co-expression of Skp and FkpA chaperones improves cell viability and alters the global expression of stress response genes during scFvD1.3 production.

Microb Cell Fact · 2010 · PMC2868799 · PMID 20388215

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a clear trendno p-value reported

Global gene expression analysis of the scFvD1.3 cells over the chaperone-expressing cells showed a clear trend of up-regulation for genes involved in heat-shock response and protein misfolding, including several genes belonging to the major HSP70 DnaK chaperone family and key proteases of the Clp and lon protease systems.

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