Sleep, aging, and lifespan in Drosophila.

The regression coefficient relating hazard to daily sleep amount, averaged across the first 2 or 4 weeks of age, was negative and highly significant in Hk 1 and Hk Y mutants but not in Hk 2 mutants (Table 1A ), and similar results were also found in wild-type siblings of the same fly lines (Table 1B ).

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Total sleep time showed a trend to increase in all lines with age, but the effect was most pronounced in Hk 1 and Hk Y flies.

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